I think the comic is trying to illustrate the difference between people who consider Y to be the vertical axis or z to be the vertical axis.

I think the right hand rule vs left hand rules coordinate systems was a mistake.

There are clearly more than two. In the top image that z-axis is pointing in the wrong direction.

Are they still underpants if you’re wearing them over pants?

There will always be one kid who will try and find something to bully someone else about.

Not American, not circumcised and I never want to be.

Done